CHROMOSOME BANDS 3P14.2, 9P21, AND 13Q14 ARE FREQUENTLY DELETED IN ROENTGENOGRAPHICALLY OCCULT BRONCHOGENIC SQUAMOUS-CELL CARCINOMA OF THE LUNG

Roentgenographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly within the bronchial wall and are thought to be a good model for elucidating chromosomal alterations during lung cancer progression. In this study, we analyzed allelic lo sses on chromosome regions 1p36, 3p14.2, 9p21, 10q25.3-q26.1, 13q14.12 -q14.2, and 16q24.1-q24.2, in which there are putative tumor suppresso r genes that may play roles in lung carcinogenesis. Forty-five cases w ith roentgenographically occult bronchogenic squamous cell carcinoma ( ROC) and 47 cases of bronchogenic carcinoma with abnormal shadows (roe ntgenographically nonoccult bronchogenic squamous cell carcinoma [RNOC ]) were examined. Highly frequent LOHs in both ROCs and RNOCs were obs erved in chromosome regions 3p14.2, 9p21, and 13q14.1-q 14.2. LOHs wer e more frequently observed in RNOCs than in ROCs at two loci: 10q25.3- q26.1 and 16q24.1-q24.2. These results suggested that (1) putative tum or suppressor genes exist on 3p14.2, 9p21, 10q25.3-q26.1, 13q14.12-q14 .2, and 16q24.1-q24.2, which may play important roles in lung carcinog enesis; (2) mutations in genes at 3p14.2, 9p21, and 13q14. 12-q14.2 re present rather early events in lung carcinogenesis; and (3) mutations in genes on 10q25.3-q26.1 and 16q24.1-q24.2 represent rather late even ts. Genes Chromosomes Cancer 23:367-370, 1998. (C) 1998 Wiley-Liss, In c.