NOSOCOMIAL INFECTIONS - PROSPECTIVE SURVEY OF INCIDENCE IN 5 FRENCH INTENSIVE-CARE UNITS

Objective: To assess the incidence and to evaluate the feasibility of inter-unit: continuous surveillance of intensive care unit (ICU)-acqui red infections. Design: Prospective multicentre, longitudinal, inciden ce survey. Setting: Five ICUs in university hospitals in western Franc e. Patients: All patients admitted to the ICU during two 3-month perio ds (1994-1995). Measurements and results: The main clinical characteri stics of the patients, ICU-acquired infections, length of exposure to invasive devices and the micro-organisms isolated were analysed. The s tudy included 1589 patients (16 970 patient-days) and the infection ra te was 21.6 % (13.1% of patients). The ventilator-associated pneumonia rate was 9.6 %, sinusitis 1.5 %, central venous catheter-associated i nfection 3.5 %, central venous catheter-associated bacteraemia 4.8 %, catheter-associated urinary tract infection 7.8 % and bacteraemia 4.5 %. The incidence density rate of ICU-acquired infections was 20.3 part s per thousand patient-days. Ventilator-associated pneumonia and sinus itis rates were 9.4 and 1.5 parts per thousand ventilation-days, respe ctively. Central venous catheter-associated infection and central veno us catheter-associated bacteraemia rates were 2.8 and 3.8 parts per th ousand catheter-days, respectively. The catheter-associated urinary tr act infection rate was 8.5 parts per thousand urinary catheter-days an d the bacteraemia rare 4.2 parts per thousand patient-days. Six indepe ndent risk factors for ICU-acquired infection were found by stepwise l ogistic regression analysis: absence of infection on admission, age > 60 years,length of stay, mechanical ventilation, central venous cathet er and admission to one particular unit. A total of 410 strains of mic ro-organisms were isolated, 16.8 % of which were Staphylococcus aureus (58.0 % methicillin-resistant). Conclusion: This prospective study us ing standardised collection of data on the ICU-acquired infection rate in five ICUs identified six risk factors. It also emphasized the diff iculty of achieving truly standardised definitions and methods of diag nosis of such infections.