RENAL TOLERABILITY OF TEICOPLANIN IN A CASE OF NEONATAL OVERDOSE

The literature does not contain reports regarding teicoplanin overdose in newborns. In a neonate with a history of recent postasphyctic acut e renal failure which recovered within 7 days of life, antibiotic ther apy with teicoplanin was started for sepsis due to Staphylococcus homi nis. However, for 5 days the dosage was excessive (20 mg/kg twice dail y instead of an initial dose of 16 mg/kg and then doses of 8 mg/kg onc e daily). Once this error had been noted, therapy was immediately susp ended. Clinically the newborn had improved and blood culture at the en d of the therapy was negative. Biohumoral tests revealed constantly no rmal levels of serum creatinine, serum cystatin C and blood nitrogen. Urinary parameters of tubulotoxicity were also within normal values. U rinary epidermal growth factor was increased. Teicoplanin was well tol erated at the renal level in the newborn even in this case of excessiv e dosage.