PROLONGED SURVIVAL OF STAGE-IV MALIGNANT MIXED MULLERIAN TUMOR OF THEOVARY AFTER CARBOPLATIN, MESNA, IFOSFAMIDE, AND CISPLATIN CHEMOTHERAPY - CASE-REPORT

Malignant mixed mullerian tumors (MMMT) of the ovary are rare, aggress ive and rapidly progressive tumors. According to the available literat ure, the presence of metastatic disease rarely permits long term survi val. We report on a 64-year old patient with stage IV ovarian MMMT who achieved a surgically-documented complete response (CR) after 6 cycle s of carboplatin, mesna, ifosfamide, cis-platin. Pelvic recurrence was diagnosed 14 months later; the patient received 6 cycles of the same regimen used as first-line chemotherapy which resulted in a second com plete response lasting for 4 months. The patient died 37 months after initial diagnosis due to intestinal occlusion. In the current case Ca 125 was significantly increased at clinical presentation of disease bu t not at the time of recurrence.