MECHANISM OF DOUBLE-STRAND DNA CLEAVAGE EFFECTED BY IRON-BLEOMYCIN

Authors
KOBAYASHI T GUO LL NISHIDA Y
Citation
T. Kobayashi et al., MECHANISM OF DOUBLE-STRAND DNA CLEAVAGE EFFECTED BY IRON-BLEOMYCIN, Zeitschrift fur Naturforschung. C, A journal of biosciences, 53(9-10), 1998, pp. 867-870
Citations number
13
Categorie Soggetti
Biology,Biology
Journal title
Zeitschrift fur Naturforschung. C, A journal of biosciences → ACNP
ISSN journal
09395075
Volume
53
Issue
9-10
Year of publication
1998
Pages
867 - 870
Database
ISI
SICI code
0939-5075(1998)53:9-10<867:MODDCE>2.0.ZU;2-L
Abstract
We have observed that in the absence of hydrogen peroxide the Fe(III)- bleomycin (BLM) complex exhibits high DNA cleavage efficiency, convert ing supercoiled Form I DNA(pBR322 or phi x174) to Form II (nicked, rel axed circular); the present study may give an important clue to elucid ate the fact that iron-bleomycin mediated double-strand DNA cleavage r equires at least one molecule of oxygen (O-2) over the amount required to form ''activated bleomycin''.