PHARMACOKINETIC PARAMETERS AND MILK CONCENTRATIONS OF KETOPROFEN AFTER ADMINISTRATION AS A SINGLE INTRAVENOUS BOLUS DOSE TO LACTATING GOATS

Six clinically normal lactating does were administered ketoprofen (2.2 mg/kg intravenously (i. v.)), Blood and milli samples were collected prior to and for 34 h after drug administration, Drug concentrations i n serum and mill; were determined by high performance liquid chromatog raphy. Pharmacokinetic parameters from each goat were combined to obta in mean estimates (mean +/- SD) of half-life of elimination (t(1/2 bet a)) of 0.32 +/-14 h, systemic clearance (Cl) of 0.74 +/- 0.12 L/kg.h, and volume of distribution at steady state (V-ss,) of 0.23 +/- 0.051 L /kg. In milk ketoprofen was unmeasurable by the method employed (level of detection 25 ng/mL) for all samples.