INCREASED PARENTAL AGE AND NUMBER OF PREGNANCIES IN KLIPPEL-TRENAUNAY-WEBER-SYNDROME

The Klippel-Trenaunay-Weber syndrome (KTWS) is generally thought to oc cur sporadically, following a somatic mutation model. However, in some cases, clinical manifestations of the syndrome have been found in fam ily members, suggesting an autosomal dominant inheritance. Here we pre sent an epidemiological analysis of a consecutive series of cases with KTWS identified in the Spanish Collaborative Study of Congenital Malf ormations (ECEMC). We found an increase in parental age and in the num ber of pregnancies, as well as familial occurrence of haemangiomas. Th ese observations suggest a genetic contribution to the occurrence of K TWS.