Population samples from Liguria, Piacenza and Pavia provinces, and Nor
th Lombardy are compared for surnames and HLA gene frequencies. The ge
netic structure inferred from the principal coordinate analysis of sur
name frequencies is different from that inferred from HLA gene frequen
cies. The latter may represent ancient migrations, since surnames are
relatively recent genetic markers dating from A.D. 1500. Ligurian and
Celts were the ancient inhabitants of this northern Italy geographic a
rea. Genetic distances, derived from HLA gene frequencies, and represe
nted with an unrooted tree show the presence of a Ligurian and a Celti
c pole. The aggregation of the subpopulations to each pole accords wit
h the history and the archaeological findings in the area.