ANTIBACTERIAL EFFECT OF SOME 2,6-DISUBSTITUTED 4-ANILINOQUINAZOLINES

Two synthetic 2,6-disubstituted 4-anilinoquinazolines exerted a signif icant effect on the G(+) bacteria Bacillus subtilis and Staphylococcus aureus: None of 12 tested derivatives influenced Escherichia coli, Pr oteus mirabilis and Pseudomonas aeruginosa. Derivatives having the aro matic ring non-substituted or substituted by bromine, the pyrimidine r ing by phenyl, morpholine or piperidine and the aniline skeleton non-s ubstituted or substituted by methyl or amino group exterted a consider able antibacterial activity.