CELL-CYCLE CONTROL OF CHROMOSOMAL DNA-REPLICATION

Accurate replication and segregation of chromosomal DNA is essential f or high-fidelity transmission of genetic information from generation t o generation. Eukaryotic cells typically replicate by first duplicatin g their chromosomes during the S phase followed by their segregation b etween two daughter cells during the M phase. Over recent years, advan ces in our understanding of this process at the molecular level have b een incredibly rapid. The present review will focus on molecular contr ol of DNA replication and the mechanisms which operate to ensure that once replicated, chromosomes are not rereplicated in the same cell cyc le.