INHIBITORY EFFECTS OF PRIOR LOW-DOSE X-RAY-IRRADIATION ON FE3-NTA-INDUCED HEPATOPATHY IN RATS()

Blood activities of hepatocellular enzymes such as lactate dehydrogena se (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal in jection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such a s alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originat ing in the capillary bile ducts or bile secretory liver cells were als o released into the blood between 6-24 hours after intraabdominal inje ction of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occur red in rat hepatic cell membranes, reaching a peak 6 hours after intra abdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dis mutase (SOD) activities and suppressed above-mentioned symptoms of tra nsient hepatopathy in rats.