LONG SURVIVORS WITH KI-1 LYMPHOMA HAVING T(2-5) (P23-Q35) - DOES THE PRESENCE OR ABSENCE OF T(2-5) INFLUENCE THE PROGNOSIS OF PATIENTS WITHKI-1 LYMPHOMA

We experienced three patients with CD30+ diffuse large cell lymphoma h aving chromosomal abnormalities. The first patient was an 8-year-old g irl with bilateral cervical lymphadenopathy. A biopsy of a cervical ly mph node revealed diffuse large cell lymphoma (stage III), positive fo r CD30 and a chromosomal abnormality, t(2;5). She attained a remission and is now in complete remission 108 months after diagnosis, despite frequent relapses. The second patient was a 13-year-old boy with right axillar and supraclavicular lymph-node adenopathy. A biopsy of a cerv ical lymph node revealed diffuse large cell lymphoma (stage III), posi tive for CD30 and a chromosomal abnormality, t(2;5). He attained remis sion and was in continuous first remission 112 months after diagnosis. The third patient was an Ii-year-old boy with fever and bilateral cer vical lymph node revealed diffuse large cell lymphoma (stage Iii), pos itive for CD30 and chromosomal abnormality without t(2;5). He showed a very aggressive clinical course. Only the patients with Ki-l lymphoma having t(2;5) survived over 100 months from the diagnosis, despite th e advanced stage of the disease. These findings and a review of the Li terature showed that the presence or absence of t(2;5) may influence t he outcome of Ki-1 lymphoma.