Clozapine was administered to 28 resistant schizophrenics at psychiatr
ic services in Bologna. At 26 weeks 62% responded. Positive and negati
ve symptoms improved, but decrease of negative symptoms partially depe
nded upon improvement of positive and EPS. No cases of agranulocytosis
were seen. Some drop-outs were related to difficulties with psychopat
hological improvement. (C) 1998 Elsevier, Paris.