UNPRECEDENTED BASE-PROMOTED OXIDATION OF IMIDAZO[1',5' 1,2]PYRIDO[3,4-B]INDOLES/

Authors
DELAFIGUERA N GARCIALOPEZ MT HERRANZ R GONZALEZMUNIZ R
Citation
N. Delafiguera et al., UNPRECEDENTED BASE-PROMOTED OXIDATION OF IMIDAZO[1',5' 1,2]PYRIDO[3,4-B]INDOLES/, Heterocycles, 48(10), 1998, pp. 2061-2070
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
10
Year of publication
1998
Pages
2061 - 2070
Database
ISI
SICI code
0385-5414(1998)48:10<2061:UBOOI1>2.0.ZU;2-E
Abstract
Dioxotetrahydro-1H-imidazo[1',5':1,2]pyrido[3,4-b] indole derivatives show a high tendency towards the oxidation at the 11b-bridgehead posit ion in basic media. This oxidation, affording the corresponding 11b-hy droxy derivatives, is produced by reaction between atmospheric oxygen and the imidazopyrido derivative under the enol form and can be suppre ssed by working in inert atmosphere. In marked contrast, these imidazo [1',5':1,2]pyrido derivatives are completely stable in acidic conditio ns.