SHARED EPITOPE HOMOZYGOSITY IS STRONGLY ASSOCIATED WITH RHEUMATOID-ARTHRITIS IN TURKEY

Objective. Associations with HLA-DRB alleles, implicated in the aetiop athogenesis of rheumatoid arthritis (RA), are found to be different in various ethnic groups. This study aimed to investigate DRB1 alleles i n RA patients in Turkey.Methods. The DRB region of the MI-IC was scree ned by polymerase chain reactian/sequence-specific oligonucleotide (PC R/SSO) hybridizations in 101 seropositive Rh patients and compared wit h 101 healthy controls. Results. Significant differences were in the f requencies of DRB10404 (12 vs 1, P = 0.003, OR = 13.5), *0401 (19 vs 4, P = 0.001, OR = 5.6) and 0408 (5 vs 0, P = 0.06, OR = 11.6) betwee n RA patients and controls. The shared epitope (SE) was present in 70. 2% of RA patients compared to 31.6% of controls (P < 0.0001, OR = 5.1) . A double dose of SE was considerably more frequent in the RA group ( 21 vs 1, P < 0.0001, OR = 26.5). Conclusion. These results support the reported positive association of RA with SE in seropositive patients in Turkey, and emphasize 'SE homozygosity' as the most strongly associ ated genetic susceptibility marker for RA.