NEUROPSYCHIATRIC SYSTEMIC LUPUS-ERYTHEMATOSUS AND THE SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC-HORMONE - A CASE-REPORT WITH VERYLATE-ONSET SYSTEMIC LUPUS-ERYTHEMATOSUS

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH ) associated with neuropsychiatric lupus (NP-SLE) is rare. We report a case of SIADH associated with the new onset of SLE in an 88-yr-old fe male. The unique features of this case include the extreme age of onse t of SLE presenting with neuropsychiatric manifestations and positive antiribosomal P antibody titres. Both the NP manifestations of SLE and SIADH were highly correlated with the SLE disease activity. This case illustrates a novel presentation of NP-SLE with SIADH which may devel op due to antibody-mediated hypothalamic dysfunction.