BIOMIMETIC PROTEIN IMMOBILIZATION USING LIPID BILAYERS

Biosensors typically consist of a transducer (sensing pad) coated with biomolecules capable of acting as receptors for an analyte in solutio n to which the device is then exposed. The overall response of the bio sensor is determined not only by the characteristics of the sensing pa d, but also by the characteristics of the biomolecular receptor (captu re) layer. This paper describes how lipid bilayers can be used advanta geously to create stable protein monolayers on a transducer surface. ( C) 1998 Elsevier Science S.A. All rights reserved.