LONG-TERM RECORDING-SYSTEM BASED ON FIELD-EFFECT TRANSISTOR ARRAYS FOR MONITORING ELECTROGENIC CELLS IN CULTURE

This paper describes the use of a PC-based system for acquisition and processing of data recorded from electrical active and excitable cells cultured over microfabricated arrays of field-effect transistors. Usi ng these recording devices, limitations of conventional recording tech niques such as those associated with making long-term and multisite re cordings can be overcome. This system has been tested using neonatal r at cardiac myocytes, the beating of which is correlated with simultane ous recorded intra- and extracellular voltage measurements. (C) 1998 E lsevier Science S.A. All rights reserved.