ELECTROCONDUCTING POLYMERS FOR THE CONSTRUCTION OF DNA OR PEPTIDE ARRAYS ON SILICON CHIPS

We wish to show in this paper new developments and new applications of the pyrrole copolymerization process allowing the addressing of pyrro le-modified biomolecules on microelectrode arrays. Two main developmen ts are described: the first one concerns the development of multiplexe d silicon chips bearing 128 microelectrodes instead of 48 for the pass ive chips. The second one deals with new applications of this grafting process concerning not only DNA chips but peptide chips too. In this way, copolymerization of pyrrole peptides on the chip (leading to pept ide chip) and their immunological detection is illustrated. This techn ology shows a high dimensional resolution and a real versatility. (C) 1998 Elsevier Science S.A. All rights reserved.