ON STEROIDS - PART CCCXCIX - HYDROGENATION OF A TETRASUBSTITUTED DOUBLE-BOND - SYNTHESIS OF 5-METHYL-19-NOR-5-BETA-PREGNANES

Authors
KASAL A POLMAN J BUDESINSKY M
Citation
A. Kasal et al., ON STEROIDS - PART CCCXCIX - HYDROGENATION OF A TETRASUBSTITUTED DOUBLE-BOND - SYNTHESIS OF 5-METHYL-19-NOR-5-BETA-PREGNANES, Collection of Czechoslovak Chemical Communications, 63(10), 1998, pp. 1549-1563
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
63
Issue
10
Year of publication
1998
Pages
1549 - 1563
Database
ISI
SICI code
0010-0765(1998)63:10<1549:OS-PC->2.0.ZU;2-P
Abstract
Reduction of C=C and/or C=O bonds in 5-methyl-19-nor-5 beta-pregn-9-en e-3,20-dione (1) leads to saturated and unsaturated ketones and hydrox y ketones. The C=C reduction affords mainly 9 beta,10 beta and 9 alpha ,10 beta dihydro products. Reaction conditions of partial esterificati on, hydrolysis and oxidation were elaborated. Several analogues were p repared for the testing of gestagenic and neurosteroidal activities.