DIVERSITY AND COMPLEXITY OF CERAMIDE SIGNALING IN APOPTOSIS

Authors
OKAZAKI T KONDO T KITANO T TASHIMA M
Citation
T. Okazaki et al., DIVERSITY AND COMPLEXITY OF CERAMIDE SIGNALING IN APOPTOSIS, Cellular signalling, 10(10), 1998, pp. 685-692
Citations number
88
Categorie Soggetti
Biology,"Cell Biology
Journal title
Cellular signalling → ACNP
ISSN journal
08986568
Volume
10
Issue
10
Year of publication
1998
Pages
685 - 692
Database
ISI
SICI code
0898-6568(1998)10:10<685:DACOCS>2.0.ZU;2-W
Abstract
Sphingolipid ceramide has emerged as a lipid messenger of cell functio ns including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological fact ors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generatio n to execute apoptosis. The review summarises the diversity and comple xity of up- and downstream of ceramide signalling in apoptosis and cli nical implications of ceramide induced apoptosis. CELL SIGNAL 10;10:68 5-692, 1998. (C) 1998 Elsevier Science Inc.