H. Satoh et al., EFFECTS OF HOCHU-EKKI-TO (TJ-41), A HERBAL MEDICINE IN COMBINATION WITH SN-38 IN CULTURE, Cancer research, therapy & control, 5(2), 1998, pp. 107-111
The present study demonstrates the enhancement of antitumor activity o
f SN-38, which is one of the key drugs of chemotherapy for lung cancer
, by Hochu-Ekki-to(TJ-41, a herbal medicine) in two human lung cancer
cell lines. TJ-41 by itself at high concentrations possessed only negl
igible activity on the human lung cancer cells used. However, treatmen
t by TJ-41 for 36 h followed by SN-38 for 36 h resulted in 4.5 to 8.9-
fold reduction in the SN-38 IC50 values in these cell lines. Our resul
ts suggested that TJ-41 might enhance the antitumor activity of SN-38.