Dj. Hosking et al., EVIDENCE THAT INCREASED CALCIUM INTAKE DOES NOT PREVENT EARLY POSTMENOPAUSAL BONE LOSS, Clinical therapeutics, 20(5), 1998, pp. 933-944
Calcium's ability to prevent bone loss in early postmenopausal women i
s controversial. We used data on 394 women from the placebo group of t
he Early Postmenopausal Interventional Cohort study, a clinical trial
of alendronate, to investigate the relation of calcium intake to bone
loss. Calcium intake was recorded, and bone mineral density (BMD) (in
the lumbar spine, total body, forearm, and hip) and biochemical marker
s of bone turnover (serum total alkaline phosphatase, serum osteocalci
n, and urinary N-telopeptide crosslink levels) were measured at baseli
ne and annually thereafter. Women whose baseline calcium intake was <5
00 mg/d were advised to increase their calcium intake. Mean (+/- SE) B
MD decreased by 1.9% +/- 0.16% at the lumbar spine and 1.6% +/- 0.14%
at the hip over the 24-month period. Despite wide variations in baseli
ne calcium intake and changes in calcium intake, these measures were n
ot significantly associated with changes in BMD or bone turnover. Even
women whose total calcium intake was >1333 mg/d (the highest tertile
of total calcium intake) showed a decline in BMD of almost 2%, similar
to declines in the lower two tertiles of total calcium intake (<869 a
nd 869-1333 mg/d, respectively). Increased calcium intake resulted in
modest mean increases of approximately 200 mg/d. We were unable to dem
onstrate that increases of this magnitude or much greater(1 g/d) were
protective against declines in BMD at any site, even in women who had
the lowest calcium intake at baseline. In addition to adequate calcium
intake, more effective therapy appears to be required when the therap
eutic goal is to increase or maintain BMD.