ANTIOXIDANT POTENTIAL, OXIDATION RESISTANCE AND MDA LEVELS OF CANCEROUS AND NONCANCEROUS HUMAN COLORECTAL TISSUES

Antioxidant potential (AOP), oxidation resistance (OR) and malondialde hyde (MDA) levels of cancerous and non-cancerous adjacent colorectal t issues from 13 patients with colorectal adenocancer were measured to i nvestigate oxidant/antioxidant status of the tissues. AOP of the cance rous tissues was found to be significantly lower than that of non-canc erous ones. However, OR and MDA levels of cancerous tissues were not d ifferent from those of non-cancerous ones. In the correlation analysis carried out between analysis parameters, significant differences were found in the cancerous tissues. Results show that AOP of cancerous co lorectal tissues is lower than that of non-cancerous adjacent ones but OR and MDA levels are not changed. We suggest that although there is an inability in the antioxidant defense system, this does not lead to oxidant stress and to peroxidation reactions in the cancerous colon ti ssues, possibly due to lowered oxidative metabolism in the cancerous c olorectal tissues.