GENOMIC ORGANIZATION AND CHROMOSOME LOCALIZATION TO BAND 19P13.3 OF THE HUMAN AES GENE - GENE-PRODUCT EXHIBITS STRONG SIMILARITY TO THE N-TERMINAL DOMAIN OF DROSOPHILA ENHANCER OF SPLIT-GROUCHO PROTEIN

The human Amino Enhancer of Split (AES) gene encodes a protein of 197 amino acids exhibiting strong similarity to the N-terminal domain of D rosophila Enhancer of Split Groucho (ESG) protein. The nucleotide sequ ence of approximately 12 kb from the human AES gene was determined, an d its protein-encoding sequence was shown to be interrupted by six int rons. The human AES gene was further localized by fluorescence in situ hybridization to chromosome band 19p13.3 near the transcription facto r 3 (TCF3) gene.