Nonsteroidal anti-inflammatory drugs (NSAIDs) have been recently relea
sed as over-the-counter drugs making them more widely available to the
general public. We present five cases of adolescents with complicatio
ns, including acute and chronic renal failure, related to the use of N
SAIDs. Risk factors for NSAID nephrotoxicity include chronic illness,
dehydration, ethanol and use of other medications. Adolescents should
be educated about the risks and prevention of NSAID toxicity. (C) Soci
ety for Adolescent Medicine, 1998