MULTIPLE FOLLICULAR HAMARTOMAS WITH SWEAT GLAND AND SEBACEOUS DIFFERENTIATION, VERMICULATE ATROPHODERMA, MILIA, HYPOTRICHOSIS, AND LATE DEVELOPMENT OF MULTIPLE BASAL-CELL CARCINOMAS

We describe a 46-year-old woman with multiple symmetrical papulocystic lesions on the face, neck, chest, back, and upper arms since childhoo d. Vermiculate atrophoderma, entropion, and progressive loss of eyelas hes was also noted. Since the age of 30, 12 basal cell carcinomas have developed on the face. Histopathologic examination revealed multiple anastomosing nests and strands that arose from the lower part of a hai r follicle in early lesions. In more advanced lesions, multiple kerati nizing microcysts within a moderately sclerotic stroma were noted in t he upper and mid dermis. In some biopsy specimens, focal areas showing sweat gland (ductal) and sebaceous differentiation were also observed . Basal cell carcinomas developed from the basaloid component of the h amartomatous proliferation.