MECHANISTICALLY DIVERSE ENZYME SUPERFAMILIES - THE IMPORTANCE OF CHEMISTRY IN THE EVOLUTION OF CATALYSIS

Authors
GERLT JA BABBITT PC
Citation
Ja. Gerlt et Pc. Babbitt, MECHANISTICALLY DIVERSE ENZYME SUPERFAMILIES - THE IMPORTANCE OF CHEMISTRY IN THE EVOLUTION OF CATALYSIS, Current opinion in chemical biology, 2(5), 1998, pp. 607-612
Citations number
39
Categorie Soggetti
Biology,Biophysics
Journal title
Current opinion in chemical biology → ACNP
ISSN journal
13675931
Volume
2
Issue
5
Year of publication
1998
Pages
607 - 612
Database
ISI
SICI code
1367-5931(1998)2:5<607:MDES-T>2.0.ZU;2-J
Abstract
The strategy that nature has used to evolve new catalytic activities f rom pre-existing enzymes (i.e. retention of substrate binding or of ca talytic mechanism) has been controversial. Recent work supports a stra tegy in which a partial reaction, catalyzed by a progenitor, is retain ed, and the active-site architecture is modified to allow the intermed iate generated to be directed to different products.