The present study was aimed at determining muscle inhibition (MI) and
knee extensor moments in 42 subjects with unilateral anterior knee pai
n syndrome. The results were compared to a normal, healthy population
with no history of knee injury. Also, the effects of 1 week of a nonst
eroidal anti-inflammatory drug (NSAID) on MI and knee extensor moments
were tested in a randomized controlled trial. At baseline, the involv
ed leg showed significantly higher MI than the noninvolved leg. In bot
h legs, MI was significantly higher and knee extensor moments lower th
an the corresponding values of the nonimpaired subjects. There was a d
irect relationship between knee pain during testing and the extent of
MI. Higher MI, in turn, was associated with lower knee extensor moment
s. The study demonstrated significant MI in the quadriceps muscles of
the involved and noninvolved legs of subjects with unilateral anterior
knee pain syndrome. The results indicate that the noninvolved leg can
not be considered a normal control for a contralateral injury. NSAIDs
did not affect MI or knee extensor moments, despite significantly redu
cing pain. This finding suggests that factors other than pain are resp
onsible for the MI observed in this specific subject population, or th
at after removal of pain, more time is required to fully restore muscl
e function.