Background: The prevalence of biliopancreatic disorders is high in pat
ients with periampullary diverticula. However, endoscopic retrograde c
holangiopancreatography (ERCP) in patients with the papilla deep insid
e duodenal diverticula is difficult. Methods: Two patients were includ
ed in this study, each with the papilla deep inside a diverticulum and
in whom an initial ERCP was unsuccessful. A biopsy forceps to pinch t
he duodenal mucosa distal to the papilla and pull the papilla out of t
he diverticulum and a cannula were inserted into the working channel o
f a duodenoscope together (the two-devices-in-one-channel method). Wit
h coordination of the two instruments, cannulation of the bile duct wa
s attempted. Results: In both patients ERCP was successful using this
procedure and no complications followed. Conclusions:The two-devices-i
n-one-channel method is useful when performing ERCP in patients with t
he papilla inside juxtapapillary diverticula.