EFFECT OF AMINOGUANIDINE ON LIPID-PEROXIDATION AND ACTIVITIES OF ANTIOXIDANT ENZYMES IN THE DIABETIC KIDNEY

The aim of this study was to examine lipid peroxidation and activities of key antioxidant enzymes in kidneys of rats with streptozotocin (ST Z)-induced diabetes and the effect of aminoguanidine on diabetes-induc ed alterations. Three groups, 6 rats each, were studied: control anima ls, not treated diabetic rats and rats treated with aminoguanidine (AG ; 1 g/liter of drinking water). After 6 and 12 weeks the animals were sacrificed and lipid peroxidation products and activities of antioxida nt enzymes were determined in their kidney homogenates. Malondialdehyd e (MDA) content was significantly elevated and activities of SOD and c atalase decreased in the kidneys of STZ-diabetic rats. AG treatment at tenuated the increase in MDA content and diminutions of activities of SOD and catalase in. the kidneys of diabetic rats. These results confi rm oxidative stress in the kidney of rats with STZ diabetes and point to an antioxidant effect of AG in experimental diabetes.