SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-HYDRAZINOQUINOLONES

A series of new C-7 substituted hydrazino quinolones and naphthyridine s were prepared and tested for antibacterial activity. The hydrazine b ridge at the C-7 position did not favor the antibacterial activity, wh ereas the nature of other substituents at N-1, C-5 and C-8 did noticea bly influence the antibacterial activity. The 7-(1-aminomorpholino) de rivatives exhibited superior antibacterial activity against Gram-posit ive and inferior activity against Gram-negative bacteria than the 7-(1 -aminopiperazinyl) derivatives. Substitution of the quinolone at posit ion-1 with cyclopropyl was the most beneficial for antibacterial activ ity among the series of compounds prepared. (C) Elsevier, Paris.