MULTIELECTRODE ARRAY FOR SIMULTANEOUS RECORDING OF GLUCOSE, OXYGEN AND ELECTROCORTICOGRAPHY FROM CEREBRAL-CORTEX IN EXPERIMENTAL FOCAL EPILEPSY

Delineating epileptic tissue before and during surgery is still a majo r problem. Electroencephalography (EEG), electrocorticography (ECoG), and magnetoencephalography (MEG) evaluations may not always correlate with outcome. Metabolic mapping, i.e. positron emission tomography (PE T) or single photon emission tomography (SPECT), is not practical or n ot sensitive-both spatial and temporal-enough for use in neurosurgery. Amperometric electrochemical electrodes for recording oxygen and gluc ose from nervous tissue are developed and tested in rat experimental f ocal penicillin epilepsy model. With a three-by-three array of glucose electrodes, epileptic focus is mapped. Simultaneous recordings of ECo G, oxygen and glucose levels performed. During seizure, extracellular glucose level showed a biphasic response pattern while oxygen level de creased slightly. It has been concluded that such a combined subdural grid recording might help before and during surgery. This method can b e used in ischemia and such experimental metabolic studies. (C) 1998 E lsevier Science S.A. All rights reserved.