PHENYLTRISALANINE - A NEW, C-3-SYMMETRICAL, TRIFUNCTIONAL AMINO-ACID

Authors
RITZEN A BASU B WALLBERG A FREJD T
Citation
A. Ritzen et al., PHENYLTRISALANINE - A NEW, C-3-SYMMETRICAL, TRIFUNCTIONAL AMINO-ACID, Tetrahedron : asymmetry, 9(19), 1998, pp. 3491-3496
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
19
Year of publication
1998
Pages
3491 - 3496
Database
ISI
SICI code
0957-4166(1998)9:19<3491:P-ANCT>2.0.ZU;2-B
Abstract
Two derivatives of phenyltrisalanine, a new, trifunctional amino acid, were synthesised in optically active forms. Two complementary techniq ues were employed, an HWE olefination reaction or a Heck coupling reac tion, and the resulting dehydroamino acids were hydrogenated using a c hiral Rh(I)-Et-DuPHOS catalyst. Phenyltrisalanine derivatives of excel lent stereoisomeric purities were thus obtained. (C) 1998 Elsevier Sci ence Ltd. All rights reserved.