SYNTHESIS, CHARACTERIZATION AND LECTIN-BINDING STUDY OF CARBOHYDRATE FUNCTIONALIZED SILSESQUIOXANES

Two carbohydrate-functionalized silsesquioxanes 2 and 3 have been prep ared by the reactions of (H2NCH2CH2CH2)(8)Si8O12 1 with eta-D-galactop yranosyl-(1-->4)-D-gluco-1,5-lactone and lpha-D-glucopyranosyl-(1-->4) -D-gluco-1,5-lactone; the latter (i.e. 3) possesses eight maltose-deri ved substituents and binds with Concanavalin A, while the former posse sses eight lactose-derived substituents that demonstrates selective bi nding to the hepatic asialoglycoprotein receptor.