EFFECTS AND SAFETY OF 16 MG CANDESARTAN IN PATIENTS SUFFERING FROM MODERATE AND SEVERE ESSENTIAL ARTERIAL-HYPERTENSION

Twenty-one patients with moderate and severe essential hypertension (o ccasional diastolic blood pressure at rest 105-120 mmHg) were given si ngle daily doses of 16 mg candesartan alone (4 patients) or as an adju nct (17 patients) to their previous but inadequate antihypertensive th erapy, Ambulatory 24-hour blood pressure measurements (ABPM) were take n before and after three weeks' treatment with candesartan. Overall ca ndesartan led to a significant reduction in blood pressure. Candesarta n achieved therapeutic differences in the occasional blood pressure of 26/17 mmHg, in the mean daily ABPM of 17/13 mmHg, and in the mean noc turnal ABPM of 15/12 mmHg. The study showed good long-term antihyperte nsive effects of candesartan over 24 hours, No limiting or persistent adverse events occurred. In patients with moderate and severe arterial hypertension (without treatment or with inadequate antihypertensive t reatment) a single daily dose of 16 mg candesartan alone or as an adju nct in combination is capable of reducing blood pressure to within the normal range over a period of 24 hours with outstanding tolerability. Thus, candesartan is eminently suitable as mono- and combination ther apy for treating such hypertensive patients in order to ensure a high level of compliance and to improve the prognosis for these patients.