EVIDENCE OF APOPTOSIS INDUCED BY MYOCARDIAL-ISCHEMIA - A CASE OF VENTRICULAR SEPTAL RUPTURE FOLLOWING ACUTE MYOCARDIAL-INFARCTION

Authors
TOYODA Y SHIDA T WAKITA N OZAKI N TAKAHASHI R OKADA M
Citation
Y. Toyoda et al., EVIDENCE OF APOPTOSIS INDUCED BY MYOCARDIAL-ISCHEMIA - A CASE OF VENTRICULAR SEPTAL RUPTURE FOLLOWING ACUTE MYOCARDIAL-INFARCTION, Cardiology, 90(2), 1998, pp. 149-151
Citations number
8
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Cardiology → ACNP
ISSN journal
00086312
Volume
90
Issue
2
Year of publication
1998
Pages
149 - 151
Database
ISI
SICI code
0008-6312(1998)90:2<149:EOAIBM>2.0.ZU;2-9
Abstract
Recent studies have reported that apoptosis may be induced by reperfus ion injury following ischemia in cardiomyocytes. We present a case wit h evidence of apoptosis induced by myocardial ischemia without reperfu sion. DNA fragmentation was demonstrated in the nuclei of the myocardi al cells surrounding the ventricular septal rupture following acute my ocardial infarction without reperfusion in the infarct-related left an terior descending coronary artery. This finding suggests that ischemia without reperfusion may induce apoptosis in myocardial cells.