EFFECTS OF DYNAMIC CARDIOMYOPLASTY ON LEFT-VENTRICULAR SYSTOLIC AND DIASTOLIC PERFORMANCE IN AN ACUTE CANINE MODEL

Although dynamic cardiomyoplasty (DCMP) is currently being evaluated a s an alternative to end-stage congestive heart failure, the overall re sults of DCMP are variable and inconclusive. We evaluated the effect o f classic DCMP on systolic and diastolic cardiac function in normal he art using reliable indicators which minimize the influences of load co nditions. Six experimental dogs were evaluated with the acute nonpreco nditioning model. The slope of the Linear preload recruitable stroke,w ork relationship (M-w) shelved a significant increase with latissimus dorsi muscle (LDM) stimulation (postwrap non-stimulation 59.1 +/- 6.3, postwrap stimulation 98.6 +/- 9.7 erg cm(-3).10(3); P < 0.01), and th e x-intercept (V-0) mas unchanged; these were utilized as the indicato rs of left ventricular systolic function. The constant of pressure dec ay (tau) increased after LDM wrap (prewrap 45.8 +/- 6.0, postwrap nons timulation 69.3 +/- 10.3, postwrap stimulation 72.3 +/- 13.9 ms; P < 0 .05), and the peak filling rate was unchanged after LDM wrap, which we re utilized as the indicators of diastolic function, We concluded that classic dynamic cardiomyoplasty is effective in assisting systolic ca rdiac function, but may to some degree have a detrimental effect on th e diastolic cardiac function.