AMPLIFICATION OF INT-2 AND BCL-1 GENES IN SQUAMOUS-CELL CARCINOMA OF THE LARYNX

We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases. the int-2 gene was amplified (4 2.9%) and in 4 cases, the hcl-l gene was amplified (25.0%). Go-amplifi cation of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other amplified cases were supraglottic carcinomas. Tumor specimens with int-2 amplification were associated with a significantly worse prognosis. We suggest that int-2 amplificat ion is one of the prognostic factors in laryngectomized patients with cancer of the larynx.