ULTRASOUND BIOMICROSCOPIC AND CONVENTIONAL ULTRASONOGRAPHIC STUDY OF OCULAR DIMENSIONS IN PRIMARY ANGLE-CLOSURE GLAUCOMA

Objective: To determine the biometric findings of ocular structures in primary angle-closure glaucoma (PACG). Design: An observational case series with comparisons among three groups (patients with acute/interm ittent PACG [A/I-PACG], patients with chronic PACG [C-PACG], and norma l subjects [N]). Participants: A total of 54 white patients with PACG (13 male, 41 female) were studied: 10 with acute, 22 with intermittent , and 22 with chronic types of PACG. Forty-two normal white subjects ( 11 male, 31 female) were studied as control subjects. Only one eye was considered in each patient or subject. Testing: Ultrasound biomicrosc opy (UBM) and standardized A-scan ultrasonography (immersion technique ) were performed in each patient during the same session or within 1 t o 3 days. Main Outcome Measures: The following A-scan parameters were measured: anterior chamber depth (ACD), lens thickness (LT), axial len gth (AL), lens/axial length factor (LAF), and relative lens position ( RLP). Ten UBM parameters were measured, the most important of which we re anterior chamber angle, trabecular-ciliary process distance (TCPD), angle opening distance at 500 mu m from the scleral spur (AOD 500), a nd scleral-ciliary process angle (SCPA). Results: Compared to normal s ubjects, the patients with PACG presented a shorter AL (A/I-PACG = 22. 31 +/- 0.83 mm, C-PACG = 22.27 +/- 0.94 mm, N = 23.38 +/- 1.23 mm), a shallower ACD (A/I-PACG = 2.41 +/- 0.25 mm, C-PACG = 2.77 +/- 0.31 mm, N = 3.33 +/- 0.31 mm), a thicker lens (A/I-PACG = 5.10 +/- 0.33 mm, C -PACG = 4.92 +/- 0.27 mm, N = 4.60 +/- 0.53 mm), and a more anteriorly located lens (RLP values, A/I-PACG = 2.22 +/- 0.12, C-PACG = 2.34 +/- 0.16, N = 2.41 +/- 0.15). The LAF values in A/I-PACG, C-PACG, and N w ere 2.28 +/- 012, 2.20 +/- 0.11, and 1.97 +/- 0.12, respectively. Ante rior chamber angle (A/I-PACG = 11.72 +/- 8.84, C-PACG = 19.87 +/- 9.83 , N = 31.29 +/- 9.18 degrees) and SCPA (A/I-PACG = 28.71 +/- 4.02, C-P ACG = 30.87 +/- 6.04, N = 53.13 +/- 9.58 degrees) were narrower, TCPD (A/I-PACG = 0.61 +/- 0.12 mm, C-PACG = 0.71 +/- 0.14 mm, N = 1.08 +/- 0.22 mm) and AOD 500 shorter(A/I-PACG = 0.13 +/- 0.09 mm, C-PACG = 0.2 1 +/- 0.10 mm, N = 0.36 +/- 0.11 mm) in patients with PACG. All the bi ometric differences proved statistically significant using the one-way analysis-of-variance test. Conclusions: In patients with PACG, the an terior segment is more crowded because of the presence of a thicker, m ore anteriorly located lens. The UBM confirms this crowding of the ant erior segment, showing the forward rotation of the ciliary processes. A gradual progressive shift in anatomic characteristics is discernible on passing from normal to chronic PACG and then to acute/intermittent PACG eyes.