EVIDENCE THAT [PHE(1) PSI (CH2-NH)GLY(2)]NOCICEPTIN-(1-13)-NH2, A PERIPHERAL ORL-1 RECEPTOR ANTAGONIST, ACTS AS AN AGONIST IN THE RAT SPINAL-CORD

Authors
CARPENTER KJ DICKENSON AH
Citation
Kj. Carpenter et Ah. Dickenson, EVIDENCE THAT [PHE(1) PSI (CH2-NH)GLY(2)]NOCICEPTIN-(1-13)-NH2, A PERIPHERAL ORL-1 RECEPTOR ANTAGONIST, ACTS AS AN AGONIST IN THE RAT SPINAL-CORD, British Journal of Pharmacology, 125(5), 1998, pp. 949-951
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
125
Issue
5
Year of publication
1998
Pages
949 - 951
Database
ISI
SICI code
0007-1188(1998)125:5<949:ET[P(A>2.0.ZU;2-L
Abstract
[Phe(1) psi(CH2-NH)Gly(2)]nociceptin-(1-13)-NH2, a pseudopeptide analo gue of nociceptin is an antagonist in peripheral assays. Here, using i n vivo electrophysiological recordings of dorsal horn neurones, [Phe(1 ) psi(CH2-NH)Gly(2)]nociceptin-(1-13)-NH2 appears to have agonist acti vity after spinal administration. The noxious evoked activity of the n eurones was inhibited by [Phe(1) psi(CH2-NH)Gly(2)]nociceptin-(1-13)-N H2, which was as potent as nociceptin itself.