NOVEL COMPOUNDS, 1,3-SELENAZINE DERIVATIVES, AS ANTIBACTERIAL AGENTS AGAINST ESCHERICHIA-COLI AND STAPHYLOCOCCUS-AUREUS

The antibacterial activities of several kinds of novel 4H-5,6-dihydro- 1,3-selenazine derivatives against Escherichia coli and Staphylococcus aureus were investigated. y-4-methyl-2-p-tolyl-4H-5,6-dihydro-1,3-sel enazine (TS-I), -4-hydroxy-2-p-tolyl-4H-5,6-dihydro-1,3-selenazine (TS -2), and entyl-4H-5,6-dihydro-1,3-selenazine(PS-l)exhibited strong inh ibitory activity against E. coli,and TS-1, TS-2, PS-1, yl-2-pentyl-6-p ropyl-4H-5,6-dihydro-1,3-selenazine (PS-6) and yl-2-pentyl-6-phenyl-4H -5,6-dihydro-1,3-selenazine (PS-8) also showed inhibitory activity aga inst S. aureus. 4H-5,6-dihydro-1,3-thiazines and 1,3-selenazole had no inhibitory activities against both bacteria. TS-1, TS-2, and PS-1 exh ibited marked antibacterial.activities against both Gram-negative and Gram-positive bacteria.