The most important diagnostic step in the management of patients with
severe acute pancreatitis is discrimination between interstitial-oedem
atous and necrotizing pancreatitis. Surgical decision-making is based
on clinical, bacteriological and contrast-enhanced CT-data. Persisting
or progressive systemic or local organ complications occuring despite
ICU-treatment are indicators for surgical management. Patients suffer
ing from sepsis syndrome, cardiovascular shock, multisystemic organ fa
ilure syndrome, surgical acute abdomen and persisting or progressing i
leus should be treated surgically. The surgical technique is based on
careful necrosectomy or debridement in combination with continuous or
repeated surgical evacuation of necrotic tissue, bacteria and biologic
ally active compounds. Necrosectomy and postoperative continuous local
lavage resulted in a hospital mortality of 17 % in necrotizing pancre
atitis, conservative management of necrotizing pancreatitis in a hospi
tal mortality of 6.3 %. In 1442 patients treated in a 14-year period t
he overall hospital mortality was 4.4 %.