THE ROLE OF MONOCLONAL-ANTIBODY IN THE MANAGEMENT OF PROSTATE ADENOCARCINOMA

Purpose: A study using monoclonal antibody ProstaScint was conducted to determine the role of radioscintigraphy for evaluation of patients with adenocarcinoma of the prostate. Previous evaluations determining sensitivity and toxicity for this agent were conducted in a multicente r study. Materials and Methods: ProstaScint scans were used for preope rative staging in patients presumed to be candidates for total prostat ectomy and a subsequent study was performed for the detection and loca lization of recurrent prostate cancer following definitive therapy. Re sults: The monoclonal antibody scan detected localized recurrent cance r in 43 patients who were possible candidates for external beam radiat ion therapy. Conclusions: The monoclonal antibody conjugate ProstaScin t provides additional information in detection and localization of rec urrent prostate cancer and would be helpful in the selection of patien ts for subsequent external beam radiation therapy.