Ja. Maatta et al., NEUTROPHILS SECRETING TUMOR-NECROSIS-FACTOR-ALPHA INFILTRATE THE CENTRAL-NERVOUS-SYSTEM OF BALB C MICE WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS/, Journal of neuroimmunology, 90(2), 1998, pp. 162-175
Experimental autoimmune encephalomyelitis (EAE) can be induced in resi
stant BALB/c mice by ultrasound-formed adjuvant emulsion. In contrast
to susceptible mouse strains large numbers of neutrophils secreting TN
F-ol occupied the central nervous system (CNS) of BALB/c mice with sev
ere EAE, whereas only small numbers of macrophages and CD4(+) T-cells
could be detected. CNS infiltration was preceded with activation of mi
croglial cells. Ultrasound formed adjuvant induced early IFN-gamma exp
ression in popliteal lymph nodes of BALB/c mice, whereas conventional
adjuvant induced delayed lFN-gamma production. Although the clinical o
utcome of EAE was similar to that seen in susceptible mice, the pathog
enesis was distinct having possible implications on the different form
s seen in multiple sclerosis. (C) 1998 Elsevier Science B.V. An rights
reserved.