ANTIVIRAL IN-VITRO ACTIVITY OF HYPERICUM-PERFORATUM L. EXTRACT ON THEHUMAN CYTOMEGALOVIRUS (HCMV)

Authors
AXARLIS S MENTIS A DEMETZOS C MITAKU S SKALTSOUNIS AL MARSELOS M MALAMAS M
Citation
S. Axarlis et al., ANTIVIRAL IN-VITRO ACTIVITY OF HYPERICUM-PERFORATUM L. EXTRACT ON THEHUMAN CYTOMEGALOVIRUS (HCMV), PTR. Phytotherapy research, 12(7), 1998, pp. 507-511
Citations number
42
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
12
Issue
7
Year of publication
1998
Pages
507 - 511
Database
ISI
SICI code
0951-418X(1998)12:7<507:AIAOHL>2.0.ZU;2-J
Abstract
The total methanol extract and chromatographic fractions of the extrac t of the aerial parts of Hypericum perforatum L. were investigated for their antiviral activity against human cytomegalovirus (HCMV) AD169 l aboratory strain by modification of the widely used diagnostic method 'shell-vial' culture. The plant selection was based on its traditional use against viruses of the Herpes family in Greece. The results showe d extract fraction III had the most potent antiviral activity against HCMV which was also superior to that of ganciclovir. (C) 1998 John Wil ey & Sons, Ltd.