SELECTIVE AUGMENTATION OF ANTIBODIES IN VARIOUS MUCOSAL REGIONS, AFTER INTRANASAL IMMUNIZATION WITH DIPHTHERIA IN MICE

The kinetics of antibody responses were analyzed in Various mucosal me mbranes as well as in the blood and the spleen after intranasal Vaccin ation of mice with diphtheria toroid. The results show a selective inc rease in antibody response in the respiratory area and the vagina foll owed by the gastrointestinal tract, but not in the spleen. IgG and IgM showed an increase 7 days after revaccination, followed by a rapid de cline. However, IgA peaked 3 days after revaccination and did not decl ine throughout the study.