We describe a ciliated hepatic foregut cyst that was clinically consid
ered neoplastic because it was large, bilocular, and associated with a
high serological level of carbohydrate antigen 19-9 (CA 19-9), Histol
ogically, the wall of the cyst showed characteristic pseudopapillae li
ned by ciliated stratified columnar epithelium with interspersed goble
t cells and underlying smooth muscle. The epithelium was strongly immu
noreactive for CA 19-9, We therefore conclude that large size, multilo
cularity, and elevated CA 19-9 do not exclude ciliated hepatic foregut
cysts from diagnostic consideration. (C) 1998 by Am. Coll. of Gastroe
nterology.