We show that the isotopy type of a 1-simple n-knot K is determined by
the Postnikov (n - 1)-stage of its exterior X(K), together with the ho
motopy class of the longitude lambda(K) is an element of pi(n) (X(K)).
Moreover any pair (X, j) where X is a 4-dimensional homology circle w
ith pi(1) (X) congruent to Z and j : S-4 x S-1 --> X is such that (X,
j) = (MCyl(j), S-4 x S-1) is an orientable PD6-pair is realizable by s
ome simple 4-knot. We derive complete algebraic characterizations of t
orsion free fibred simple 4-knots and of Artin spins of fibred simple
3-knots.