GROWTH-INHIBITION ACTIVITY AND ANTIADHESION ACTIVITY OF N-(SUBSTITUTED PHENYL) MALEIMIDES AGAINST MARINE ADHESIVE BACTERIUM

We prepared 29 N-(substituted phenyl)maleimides using following three methods; method A: using excess acetic anhydride, method B: using a st oichiometric amount of acetic anhydride, and method C: heating without solvent. The growth-inhibition activities of the maleimides were exam ined by the paper disk method against Escherichia coli (Gram negative) , Bacillus subtilus (Gram positive) and a Gram positive marine bacteri um. The maleimides had similar activities against Gram positive bacter ia as a whole. The activities increased with the inductive electron-do nating effect of the o-substituents of the N-phenylmaleimides against both Gram positive bacteria. We also examined the anti-adhesion activi ty in the sea of the maleimides against marine adhesive bacteria using the samples containing the maleimides in butyral resin. The anti-adhe sion activity could be correlated with the growth-inhibition activity against B. subtilus.